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目的:观察乌司他丁对急性肺损伤患者炎症因子及血气分析的影响。方法:急性肺损伤患者40例随机分为2组。在常规治疗基础上,治疗组给予乌司他丁20万u+0.9%氯化钠注射液100mL,以50mL/h速率静脉泵注,1次/d,连续使用3d。对照组给予0.9%氯化钠注射液100mL,以50mL/h速率静脉泵注,1次/d,连续使用3d。比较2组入院时、治疗后72h呼吸频率、氧分压、二氧化碳分压、氧合指数,及入院时、治疗后48,72h白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平。结果:2组治疗后72h呼吸频率均较治疗前下降(P<0.05),氧分压、二氧化碳分压、氧合指数均较治疗前增加(P<0.05),治疗组改善优于对照组(P<0.05);2组治疗后48,72h白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均较入院时下降(P<0.05),治疗组下降优于对照组(P<0.01)。结论:乌司他丁可显著抑制机体炎症介质的产生,改善急性肺损伤患者的治疗效果。
Objective: To observe the effect of ulinastatin on inflammatory factors and blood gas analysis in patients with acute lung injury. Methods: Forty patients with acute lung injury were randomly divided into two groups. On the basis of routine treatment, the treatment group was given ulinastatin 200000 u 0.9% sodium chloride injection 100mL, 50mL / h rate intravenous infusion, 1 times / d, continuous use of 3d. The control group was given 0.9% sodium chloride injection 100mL, 50mL / h rate intravenous infusion, 1 times / d, continuous use of 3d. The respiratory rate, partial pressure of oxygen, partial pressure of carbon dioxide, oxygenation index, and the levels of interleukin-6, interleukin-8, tumor necrosis factor-α Level. Results: The respiration rate of 72 hours after treatment in both groups decreased significantly (P <0.05), and the partial pressure of oxygen, partial pressure of carbon dioxide and oxygenation index both increased (P <0.05), and the improvement in the treatment group was better than that in the control group P <0.05). The levels of interleukin-6, interleukin-8 and tumor necrosis factor-α in the two groups after treatment were lower than those at admission (P <0.05) <0.01). Conclusion: Ulinastatin can significantly inhibit the production of inflammatory mediators and improve the therapeutic effect in patients with acute lung injury.