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目的:探讨思美泰与还原型谷胱甘肽治疗新生儿胃肠外营养相关性胆汁淤积(PNAC)的临床疗效。方法:将2006年2月～2010年8月诊断为胃肠外营养相关性胆汁淤积的新生儿随机分为治疗组和对照组,治疗组44例采用抗感染、肝酶诱导、思美泰、还原型谷胱甘肽治疗,对照组43例采用抗感染、肝酶诱导、肝泰乐护肝传统治疗,比较两组的疗效。结果:治疗组退黄、降酶作用明显,总有效率为95.4%,对照组总有效率为69.7%,差异有统计学意义(χ2=15.6,P<0.05)。结论:思美泰与还原型谷胱甘肽治疗PNAC能有效退黄、降酶,作用明显,未见明显不良反应。
Objective: To investigate the clinical efficacy of Simmelide and reduced glutathione in the treatment of neonatal parenteral nutrition-associated cholestasis (PNAC). Methods: Neonates diagnosed as parenteral nutrition-related cholestasis from February 2006 to August 2010 were randomly divided into treatment group and control group. In the treatment group, 44 cases were treated with anti-infection, liver enzyme induction, Reduced glutathione treatment, the control group of 43 patients with anti-infective, liver enzyme induction, Liver Tail liver protection traditional treatment, the efficacy of the two groups were compared. Results: The treatment group returned to yellow, the role of significant enzyme, the total effective rate was 95.4%, the control group, the total effective rate was 69.7%, the difference was statistically significant (χ2 = 15.6, P <0.05). Conclusion: Simei Thai and reduced glutathione treatment of PNAC can effectively yellow, reduce enzyme, the role of obvious, no significant adverse reactions.