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人类免疫缺陷病毒Ⅰ(HIV)有症状感染是一种慢性多系统疾病,伴明显免疫、淋巴网状、神经和肺脏的症状。成人获得性免疫缺陷综合征(AIDS)半数发现有肾损害,但在儿科尚未受到重视。近3年中,作者见到5例儿童AIDS伴严重肾损害,本文报告其临床过程和病理改变。方法在1984年3月至1987年3月,经儿科医院按AIDS程序确诊的175例HIV感染中,尿和/或电解质检查,大约40%有间歇异常,但临床上出现肾损害只有5例,其中3例做肾活检,2例死后尸解,肾组织均送光镜、免疫荧光和电镜检查。结果所有患儿均为围产期HIV感染,其临床出现症状时,平均年龄为24.4月(3～60月),临床出
Human immunodeficiency virus (HIV) Symptomatic infection is a chronic, multisystem disease with overt immunodeficiency, reticuloendothelial, neurological and pulmonary symptoms. Half of adult acquired immunodeficiency syndrome (AIDS) found kidney damage, but not yet pay attention in pediatrics. In the recent 3 years, the author saw 5 cases of AIDS in children with severe renal impairment. This article reports the clinical course and pathological changes. Methods From March 1984 to March 1987, among the 175 cases of HIV infection diagnosed by AIDS program in pediatric hospitals, about 40% had intermittent abnormalities in urine and / or electrolytes. However, there were only 5 cases of renal damage clinically. Three of them performed renal biopsy, and 2 died of post-mortem. The kidneys were all sent light microscopy, immunofluorescence and electron microscopy. Results All patients were perinatal HIV infection, the clinical symptoms, the average age was 24.4 months (3 to 60 months), the clinical out