神经毒素、帕金森氏综合征和帕金森氏病

• 作 者: Langston JW 林永锻
• 出 处: 国外医学.药学分册
• 发表日期: 1988年04期
• 关键词: 帕金森氏病 去氧麻黄碱 神经变性疾病 神经毒素 神经元变性疾病 毒性机理 黑质 神经元变性 氧自由基 毒性

本文简介了“毒性三价基”的生成和失活过程.介绍了锰、去氧麻黄碱和MPTP的毒性机理,它们引起帕氏征,造成DA能神经元变性死亡.人体MPTP中毒临床表现极类似于帕氏病,可能是原发帕氏病的致病因子.提出了人体神经元变性疾病的新机制,为研究神经变性疾病提供理论基础.

This article describes the formation and inactivation of “toxic trivalent bases.” The toxic mechanisms of manganese, methamphetamines and MPTP are introduced, and they cause Paclitaxel, resulting in the degeneration of DA neurons. The performance is very similar to Pars disease, which may be the causative agent of primary Pa’s disease.A new mechanism of human neuronal degenerative diseases is proposed, which provides a theoretical basis for the study of neurodegenerative diseases.