论文部分内容阅读
正常时精子抗原被隔离在血睾屏障之后,破坏此屏障完整性的因素如睾丸活检,输精管结扎或感染可引起精子抗体产生。无此种因素而发生精子免疫的男子提示遗传因素起作用,本文研究人白细胞抗原(HLA)与精子抗体所致不育相关联的可能性。 103对不育失妇和50对生育夫妇用被动血凝试验和微量精子细胞毒试验测定血清、精浆、宫颈和阴道分泌物中的抗精子抗体,用标准National Instituts of Health(NIH)淋巴细胞毒技术作A、B位点HLA定型。结果发现不育组87个男子和76个妇女有全身和/或局部抗体,50对生育夫妇和12对不育夫妇无抗体。有抗体的夫妇中54%男子和43%妇女
Normal sperm antigen is isolated in the blood testis barrier, the factors that undermine the integrity of the barrier such as testicular biopsy, vasectomy or infection can cause sperm antibodies. Men who developed sperm immunity without such a factor suggested that genetic factors play a role, and this article examines the possibility that human leukocyte antigen (HLA) is associated with infertility caused by sperm antibodies. 103 Anti-sperm antibodies in sera, seminal plasma, cervix and vaginal secretions were measured using passive hemagglutination tests and micro-sperm cytotoxicity tests on infertile women and 50 pairs of reproductive couples using standard National Institut of Health (NIH) lymphocytes Toxic technology for A, B site HLA stereotypes. As a result, 87 men and 76 women in the infertile group were found to have systemic and / or local antibodies, while 50 pairs of reproductive couples and 12 pairs of infertile couples had no antibodies. 54% of couples with antibodies and 43% of women