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在判断多发性骨髓瘤患者预后方面下列因素是有价值的:病期、血红蛋白、血小板计数、肾功能、血清钙、血浆白蛋白、乳酸脱氢酶(LDH)、C反应蛋白(CRP)、轻链类型、骨髓中浆细胞百分数。除此以外,标记指数、DNA和RNA的含量、染色体核型、β_2微球蛋白、白介素2和白介素6也都是判断预后有价值的因素,但是,由于检测方法复杂,所以很少被采用。此外,光学显微镜中浆细胞的成熟程度和电子显微镜中浆细胞核浆发育不平衡的程度均与骨髓瘤患者的预后有关。本研究分析影响年老组(≥65岁)和年轻组(<65岁)骨髓瘤患者预后的各因素,特别涉及形态学方面。
The following factors are valuable in predicting the prognosis of patients with multiple myeloma: duration of disease, hemoglobin, platelet count, renal function, serum calcium, plasma albumin, lactate dehydrogenase (LDH), C-reactive protein (CRP) Chain type, percentage of plasma cells in bone marrow. In addition, the labeling index, DNA and RNA content, chromosome karyotype, β 2 microglobulin, interleukin 2 and interleukin 6 are all valuable prognostic factors, however, they are seldom used because of the complexity of detection methods. In addition, the degree of maturation of plasma cells in an optical microscope and the degree of imbalance of plasmacytoplasmic plasma cell nuclei in electron microscopy are all related to the prognosis of myeloma patients. This study analyzed the factors that influence the prognosis of myeloma patients in the elderly (≥65 years) and younger (<65 years) groups, with particular regard to the morphological aspects.