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本文用胶质纤维酸性蛋白免疫组织化学方法研究了帕金森氏病模型鼠、老年性痴呆模型鼠及皮质损伤鼠等在脑移植２～３个月后移植区及其与宿主交界面的胶质细胞变化。结果发现不同动物模型的胚脑移植区及其与宿主交界面的胶质变化基本相同．Ｎｉｓｓｌ染色切片上可见移植区和宿主之间有直径小于８μｍ的小细胞集聚。胶质纤维酸性蛋白免疫组织化学法发现移植区和宿主脑交界面有深染的阳性纤维及细胞或交界面形成一包膜状结构；还有的在交界面无明显的胶质纤维酸性蛋白阳性纤维分隔，呈现两者相互融合的趋势．移植区内可见两种胶质细胞，一种与正常胶质细胞近似，另一种为胞体大、突起粗且深染的反应性胶质细胞；移植区内的血管周围也见有反应性胶质细胞包绕。本研究表明移植也可引起胶质反应，并且移植区内反应性胶质细胞可能对植入的神经元提供其生存所需要的营养物质。
In this study, glial fibrillary acidic protein immunohistochemical method to study the Parkinson’s disease model rats, Alzheimer’s disease model rats and cortical damage rats and other brain transplantation 2 to 3 months after transplantation and its interface with the host glial Cell changes. The results showed that different animal models of embryonic brain transplantation area and its host interface glial changes are basically the same. Nissl stained sections showed small cell aggregates smaller than 8 μm in diameter between the graft and the host. Glial fibrillary acidic protein immunohistochemistry found that the graft area and the host brain interface deep-stained positive fibers and cells or interface to form a capsule-like structure; there are no obvious interface at the glial fibrillary acidic protein-positive Fiber separation, showing a fusion of the two trends. Two kinds of glial cells were seen in the transplantation area, one was similar to the normal glial cells, the other was large cell body, protruding coarse and deep staining of reactive glia; perivascular grafts also see the area around the reactive glue Stromal cells wrap around. This study shows that transplants can also cause a glial reaction, and reactive glial cells in the transplanted area may provide implanted neurons with the nutrients they need to survive.