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对老年对照、单侧穹窿伞横断、穹窿伞横断＋隔移植及穹窿伞横断＋隔＋蓝斑联合移植等四组大鼠，在完全切断大鼠左侧穹窿伞后１０ｄ，将胚胎隔或隔＋蓝斑移植物的悬浮液注入损伤鼠双侧海马．１６周后分别用Ｍｏｒｒｉｓ水迷宫观察大鼠的学习记忆，用ＣｈＡＴ及ＴＨ染色观察移植物的生长，以ＡＣｈＥ染色观察宿主海马胆碱能纤维密度。结果表明：单侧穹窿伞横断不仅能严重地破坏大鼠的学习记忆功能，同时也使同侧海马的胆碱能纤维大量丧失；隔移植能改善损伤鼠的学习记忆功能，同时也使去胆碱能传入的海马重获胆碱能纤维的支配；隔＋蓝斑联合移植虽也能改善学习记忆功能，但作用不如隔移植，而且联合移植只提高损伤鼠海马ＣＡ１区胆碱能纤维密度，对ＣＡ３区及齿状回无作用，提示胚胎蓝斑不能协同隔移植物起作用。
Four groups of rats were randomly divided into four groups: old control group, unilateral foveal dome transection, fistula transversal transection + septal transplantation and foramenal ulnar transection + septemporal plaque transplantation. After 10 days of completely cutting off the left fimbria of rats, + The injection of the macula graft into bilateral hippocampus of injured rats. After 16 weeks, Morris water maze was used to observe the learning and memory in rats. ChAT and TH staining were used to observe the growth of the grafts. AChE staining was used to observe the cholinergic fiber density of the host hippocampus. The results showed that the unilateral foramen magnocase transection could not only severely damage the learning and memory function of rats, but also cause a large loss of cholinergic fibers in the ipsilateral hippocampus. Septal transplantation could improve the learning and memory function of rats, and at the same time, Alkaline can be introduced into the hippocampus to regain the control of cholinergic fibers; septal + locus co-transplantation can improve learning and memory function, but the effect is not as good as transplants, and combined transplantation only to improve the rat hippocampal CA1 cholinergic fiber density , No effect on the CA3 area and the dentate gyrus, suggesting that the blue spot of the embryo can not coordinate with the plants.