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[目的]探讨心肌炎患儿多重病原体的感染情况和特点,同时观察应用免疫球蛋白治疗效果。[方法]采用ELISA法,检测患儿血清柯萨奇病毒B组(CoxB)、单疱病毒(HSV)、巨细胞病毒(CMV)、风疹病毒(RubV)、弓形体抗体(Tox)、支原体(MP)和EB病毒抗体。检出多重感染42例,将多重感染患者分为治疗组和对照组各21例分别进行治疗。[结果]治疗组缓解率85.7%(18/21),高于对照组52.4%(校正2=4.011,P=0.045)。[结论]小儿心肌炎存在多种病原体混合感染,静脉使用免疫球蛋白治疗可较快缓解症状。
[Objective] To investigate the infection status and characteristics of multiple pathogens in children with myocarditis and to observe the effect of immunoglobulin therapy. [Method] The levels of CoxB, HSV, CMV, RubV, Tox, Mycoplasma (Mycoplasma pneumoniae) MP) and Epstein-Barr virus antibodies. Forty-two cases of multiple infections were detected, and 21 patients with multiple infections were divided into treatment group and control group. [Results] The response rate of the treatment group was 85.7% (18/21), which was higher than that of the control group (52.4%) (adjusted 2 = 4.011, P = 0.045). [Conclusion] Mixed infection of many pathogens exists in children with myocarditis. Intravenous immunoglobulin treatment can relieve symptoms quickly.