论文部分内容阅读
茶碱和β-肾上腺受体拮抗剂叔丁喘宁联合用药治疗哮喘时,经研究发现,两药同时服用使副作用增加。引起这些副作用的原因,可能是由于与药代动力学有关的相互作用。这促进了对茶碱和叔丁喘宁在稳态时的药代动力学研究。现发现茶碱和叔丁喘宁在白天与夜间的药代动力学上(时间药代动力学)可能有差异。经对12位健康受试者单独或联合给予叔丁喘宁(7.5 mg,1日2次,缓释片)和茶碱(300mg,1日2次,缓释片)7d,在第7天早晨服药之后,收集12 h内的血样与尿样;同一天晚间服药之后,采集48 h内的血样与尿样;分析测定诸样品中叔丁喘宁与茶碱(包括茶碱体内代谢物)的量。计算血药浓度曲线下的面积(AUC)、血药浓度的波动、平均残留时间、消除半衰期、肾消除以及稳态时的
Theophylline and β-adrenergic receptor antagonist tert-butyl asthma combined treatment of asthma, the study found that the two drugs at the same time taking side effects. The causes of these side effects may be due to pharmacokinetic-related interactions. This facilitated pharmacokinetic studies of theophylline and terbutaline at steady state. Theophylline and terbutaline are now found to be different in pharmacokinetics (time pharmacokinetics) between day and night. Twelve healthy subjects were given either Tebutetine (7.5 mg twice a day for 2 days) and theophylline (300 mg twice a day for 7 days) for 7 days. On the 7th day Blood samples and urine samples were collected within 12 h after taking the drug in the morning. Blood samples and urine samples were collected within 48 h after the medication was taken on the evening of the same day. Tocetyltrazine and theophylline (including the theophylline in vivo metabolites) The amount of. Calculate area under the plasma concentration curve (AUC), fluctuations in plasma concentration, mean residual time, elimination half-life, renal elimination, and steady-state