氨苯砜治疗的规则性和畸形发生的关系

• 作 者: 张国成
• 出 处: 国外医学.皮肤病学分册
• 发表日期: 1989年02期
• 关键词: 畸形发生 氨苯砜 麻风患者 南印度 寿命表 瘤型麻风 畸形率 规则治疗 畸形病 危险性

作者对南印度5746例已经用氨苯砜治疗数年的麻风患者回顾性地作了关于氨苯砜治疗的规则性与畸形发生之间的相关研究。这些患者疗前均无畸形,疗中所发生的畸形,除感觉丧失外,均作了详细记录。结果发现589例在以后5年的治疗期内发生了畸形。应用寿命表方法计算,其5年的畸形发生率为11.1%,畸形发生部位是:手46%,足52%,面15%,眼3%。

The authors retrospectively conducted a study on the relationship between the regularity of dapsone treatment and the incidence of deformity in 5746 leprosy patients who had been treated with dapsone in South India. None of these patients had deformities prior to treatment, and deformities that occurred during treatment were recorded in detail except for loss of sensation. The results showed that 589 cases in the next 5 years of treatment period, deformity occurred. The application of the life table method, the 5-year incidence of deformity was 11.1%, malformations were: 46% of hands, feet 52%, face 15%, 3% of the eye.