论文部分内容阅读
In recent years,various carriers for gene delivery nave been developed for biomedical applications.Among all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety.In particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy.Herein,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine(PEI),polyamidoamine(PAMAM) dendrimers,polylysine(PLL),chitosan and modified cationic polymers.And recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were summarized.Finally,the future perspectives in the development of novel polymeric carriers for delivery gene were presented.
In recent years, various carriers for gene delivery have been developed for biomedical applications. Among all kinds of gene carriers, cationic polymeric carriers for delivery therapeutic genes as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative safety .In particular, the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer therapy. Herein, this review focused on the development of cationic polymeric carriers for cancer therapy, including polyethylenimine (PEI), polyamidoamine (PAMAM) dendrimers , polylysine (PLL), chitosan and modified pharmaceutically polymers. Recent progresses in the development of novel polymeric carriers for gene delivery, such as targeted gene carriers, responsive gene carriers and multifunctional gene carriers, were summarized. Finally, the future perspectives in the development of novel polymeric carriers for delivery gene were presented.