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自六十年代初期美国科学家Jensen首次提出甾体激素受体概念以来,二十多年的努力,使人们对甾体激素在细胞和分子水平上对靶器官的作用机理又有了新的认识,随着进一步深入研究雌激素和孕激素在着床和早期妊娠等生殖过程中的调节作用,有可能通过药物来改变和控制细胞功能,从而达到人们所预期的调节生育的目的。世界卫生组织曾规划把甾体激素受体研究作为一种避孕新途径,对此Aitken和Harper作过深刻的评述,认为开展甾体激素受体的研究是有临床应用价值的。
Since the concept of steroid hormone receptor was first proposed by American scientist Jensen in the early 1960s, more than two decades of efforts have brought new perspectives on the mechanism of action of steroid hormones on target organs at the cellular and molecular level, With the further study of estrogen and progesterone in implantation and early pregnancy and other reproductive process regulation, it is possible to change and control cell function through the drug, so as to achieve the desired purpose of regulating fertility. WHO has planned to use steroid hormone receptor research as a new way of contraception. Aitken and Harper made a profound review on this and concluded that it is of clinical value to carry out research on steroid hormone receptors.