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血型物质或称A.B.H同族抗原,在各种正常组织和细胞中常具有一定的分布。当细胞发生去分化或癌变时,(包括胃癌),细胞内血型物质常呈现消失或减少,因此,有些作者试图应用血型物质作为肿瘤恶性度的指标。但到目前为止,对不同组织学类型的胃癌的血型物质消长情况;以及对胃粘膜不典型上皮增生及肠化生的血型物质变化的情况,均尚无详细的研究。本文的目的是研究胃癌的不同的组织学类型及癌前病变的血型物质的消长变化并分析其意义。材料和方法收集82例外科切除的带癌胃标本及33例具有不典型增生(其中24例伴有肠化生改变)的胃标本。采用Alcian Blue(AB)pH2.5及AB/PAS染色以显示酸性及中性粘蛋白。采用特异性红细胞粘附试验
Blood group substances, or A.B.H homologous antigens, often have a certain distribution in various normal tissues and cells. When cells undergo dedifferentiation or canceration (including gastric cancer), intracellular blood-type substances often appear to disappear or decrease. Therefore, some authors have attempted to use blood-type substances as indicators of tumor malignancy. However, to date, there have been no detailed studies on the histological types of gastric cancer, blood group substances, and the changes of gastric mucosal atypical epithelial hyperplasia and intestinal metaplasia. The purpose of this paper is to study the different histological types of gastric cancer and the changes in the blood type material of precancerous lesions and analyze their significance. Materials and Methods Eighty-two surgically resected gastric specimens with cancerous lesions and 33 gastric dysplasias (including 24 with intestinal metaplasia) were collected. Alcian Blue (AB) pH2.5 and AB/PAS staining were used to show acidic and neutral mucin. Specific Red Cell Adhesion Test