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近年发现氨茶碱有防止和纠正膈肌疲劳的作用。现就其研究的新进展综述如下: 一、膈肌疲劳的发生机理和临床表现正常人在平静呼吸时,呼气肌及呼吸辅助肌群基本上不参与收缩,而吸气肌的主要力量(约75％)来自膈肌的收缩,因此膈肌是研究吸气肌疲劳的主要对象。凡使呼吸肌作功额外增加的情况(如气道阻塞、僵硬肺、过度通气或肺过度充气等),均能增加膈肌对能量的需求。如耗能与供能之间呈负平衡,膈肌便不能产生足够的力量
In recent years, aminophylline found to prevent and correct the role of diaphragmatic fatigue. Now on the progress of their research are summarized as follows: First, the mechanism of occurrence of diaphragmatic fatigue and clinical manifestations of normal breathing in the calm, the respiratory muscles and respiratory muscles basically do not participate in constriction, and the main force of the inspiratory muscle (about 75%) from the diaphragmatic contraction, diaphragmatic muscle is the main object of study of inspiratory muscle fatigue. Any additional increase in work done to the respiratory muscles, such as airway obstruction, stiff lungs, hyperventilation, or hyperinflation of the lungs, can increase the diaphragm’s energy requirements. Diaphragm can not generate enough power if there is a negative balance between energy consumption and energy supply