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目的:观察黄花败酱甲醇提取物对溃疡性结肠炎小鼠模型的抗炎杀菌、修复溃疡方面的作用。方法:将40只小鼠随机分为4组,每组10只。SASP组连续饮用5%DSS溶液7天,并于第4天灌胃柳氮磺吡啶肠溶片0.3g/(kg·d);黄花败酱组连续饮用5%DSS溶液7天,并于第4天灌胃黄花败酱甲醇提取物50mg/(kg·d);模型组连续饮用5%DSS溶液7天,并于第4天灌胃相当剂量生理盐水,连续4天;正常对照组自由饮蒸馏水连续7天。以疾病活动指数(DA)I、组织病理学损伤为评价指标观察其疗效。结果:DAI评分SASP组、黄花败酱组与模型组比较,差异均有显著性意义(P<0.05)。给药后小鼠的组织病理学损伤均显著改善,SASP组、黄花败酱组组织学评分均较模型组降低(P<0.05),但SASP组与黄花败酱组比较,差异无显著性意义(P>0.05)。结论:黄花败酱甲醇提取物对小鼠实验性结肠炎有显著疗效。
OBJECTIVE: To observe the anti-inflammatory and bactericidal effect of methanol extract of Phellodendron L on the ulcerative colitis mouse model in repairing ulcer. Methods: Forty mice were randomly divided into 4 groups with 10 mice in each group. In the SASP group, the 5% DSS solution was continuously consumed for 7 days, and the sulfasalazine enteric-coated tablets 0.3g / (kg · d) on the 4th day. The 5% DSS solution was drank continuously for 5 days The rats in the model group received continuous 5% DSS solution for 7 days and the rats in the model group were fed with the same dose of saline for 4 days on the 4th day. The rats in the normal control group were free to drink Distilled water for 7 consecutive days. The disease activity index (DA) I, histopathological damage as an indicator to observe its efficacy. Results: There were significant differences between DAI SASP group and Huang Huatuo butter group and the model group (P <0.05). Histopathological damage of mice was significantly improved after administration, histological score of SASP group and Huang Huatan paste group were lower than that of model group (P <0.05), but no significant difference was found between SASP group and Huang Huatan paste group (P> 0.05). Conclusion: The methanol extract of Huang-huang bolus has a significant effect on experimental colitis in mice.