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目的:探讨未吸烟人群慢性阻塞性肺疾病与肺癌之间的相互关系,为预防决策提供依据。方法:计算机检索Pub Med、中文科技期刊数据库(VIP)、中国期刊全文数据库(CNKI)、万方数字化期刊全文数据库,筛选研究未吸烟人群慢性阻塞性肺疾病与肺癌之间关系的文献,对纳入的文献进行质量评价,采用Review Manager 5.3软件进行Meta分析。结果:共纳入9篇文献,包括肺癌组2 089例,对照组4 519例。Meta分析结果提示,未吸烟人群慢性阻塞性肺疾病与肺癌关系明显,合并OR值为1.46(95%CI=1.26~1.70)。这种联系在白种人明显(OR=1.58;95%CI=1.20~2.08),亚洲人中无统计学意义(OR=1.25;95%CI=0.98~1.59)。慢阻肺、慢性支气管炎、肺气肿合并OR值分别为1.46(95%CI=1.04~2.03)、1.64(95%CI=1.15~2.36)和1.47(95%CI=1.17~1.83)。结论:慢性阻塞性肺疾病与肺癌可能密切相关。
Objective: To explore the relationship between chronic obstructive pulmonary disease (COPD) and lung cancer in non-smokers and to provide evidence for prevention and treatment. Methods: The databases of Pub Med, Chinese Science and Technology Periodical Database (VIP), Chinese Journal Full-text Database (CNKI) and Wanfang Digital Periodicals were searched by computer, and the relationship between chronic obstructive pulmonary disease (NSCLC) Of the quality of the literature review, using Review Manager 5.3 software for meta-analysis. RESULTS: Nine articles were included, including 2 089 lung cancer patients and 4 519 control patients. Meta-analysis results suggest that chronic obstructive pulmonary disease in non-smokers has a significant relationship with lung cancer with a combined OR of 1.46 (95% CI = 1.26-1.70). The association was significant in Caucasians (OR = 1.58; 95% CI = 1.20-2.08), but not in Asians (OR = 1.25; 95% CI = 0.98-1.59). The OR of COPD, chronic bronchitis and emphysema were 1.46 (95% CI = 1.04 ~ 2.03), 1.64 (95% CI = 1.15 ~ 2.36) and 1.47 (95% CI = 1.17 ~ 1.83) respectively. Conclusion: Chronic obstructive pulmonary disease may be closely related to lung cancer.