日本常山叶中具松弛大鼠小肠平滑肌作用的生物碱

• 作 者: 宋丽明
• 出 处: 国外医学(中医中药分册)
• 发表日期: 2002年01期
• 关键词: 叶中 山叶 提取物 基原植物 肠平滑肌 大鼠 洗脱物 松弛反应 氯甲烷 溶解物

布于日本、朝鲜和中国的一种灌木,其茎叶在日本曾用作家畜杀虫剂,并作为生药常山的基原植物之一。本次从日本常山叶的提取物中分离出2种生物碱和常山宁(japonine)与加锡果灵(eduline),二者均具有较强的松弛小肠肌的活性。目前已从日本常山的各部位分离出20种生物碱,但加锡果灵是首次从叶中分离得到。

A shrub that is distributed in Japan, North Korea, and China, whose stems and leaves were used as livestock insecticides in Japan and as one of the basic raw plants of the crude drug Changshan. Two types of alkaloids, japonine and eduline, were isolated from the extracts of the Japanese alfalfa leaves, both of which had strong relaxing intestinal muscle activity. At present, 20 alkaloids have been isolated from various parts of Changshan, Japan, but Kasei Guoling is isolated from the leaves for the first time.