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该文旨在报道接受再照射的头颈癌患者长期疾病控制状况和放疗后的毒副作用。1986—2013年间,137例复发或二原发恶性肿瘤患者被纳入研究,这些患者接受的再照射剂量均≥45Gy。评估指标包括局部控制率、总生存率(OS)和晚期并发症≥4级[欧洲癌症研究与治疗组织(EORTC)/肿瘤放射治疗协作组(RTOG)标准]。结果:术后再照射患者5年局部控制率为46%,未手术再照射患者5年局部控制率为20%(P<0.05)。16例严重病例中(分级≥4),11例出现晚期毒副作用接受调强再照射的患
This article aims to report long-term disease control and side effects after radiotherapy in patients with head and neck cancer receiving re-irradiation. Between 1986 and 2013, 137 patients with relapsed or two primary malignancies were included in the study, and these patients received ≥45 Gy doses of radiation. Assessments included local control rates, overall survival (OS), and late complications ≥ 4 [European Organization for Research and Treatment of Cancer (RTOR) criteria]. Results: The 5-year local control rate was 46% in patients with re-radiation after surgery and 20% in 5-year without surgery and re-radiation (P <0.05). 16 cases of severe cases (classification ≥ 4), 11 cases of late toxic side effects received IMRT