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目的:探讨遗传性肠癌门诊开展的效果及注意事项。方法:收集2016年1月至2018年6月在本院就诊、接受遗传筛查和遗传咨询患者的信息，分析家族史采集、随访管理对于遗传门诊的作用。结果:通过强化家族史问诊，使肿瘤家族史的发现率提高了13.6%。认真对胚系检测确诊的156个遗传性肠癌家系进行随访管理，共检出并处理早期肠癌5例，腺瘤性息肉12例。结论:开展遗传门诊有助于规范管理遗传高危人群，需重视家族史采集和随访管理在其中的作用。“,”Objective:To explore the effect and precautions of setting up a genetic clinic for hereditary colorectal cancers.Methods:To collect the information of the patients who received genetic screening and genetic counseling at our hospital from January 2016 to June 2018, and analyze the role of family history collection and follow-up management.Results:The detection rate of family history of tumors has increased by 13.6%. Follow up management was carried out in 156 families with hereditary colorectal cancer confirmed by detection of germline mutations. Five cases of early colorectal cancers and 12 cases of adenomatous polyps were detected and treated.Conclusion:To set up genetic clinic is helpful to standardize the management of high-risk population, and attention should be paid to the role of family history collection and follow-up management.