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目的探究性别和经介入治疗的B型急性主动脉夹层(acute aortic dissection,AAD)患者的长期预后的关系。方法采用回顾性、观察性研究,选取2012年1月—12月所有经介入治疗的B型AAD患者,按性别不同分为男女2组,采用Kaplan-Meier生存曲线分析评估不同性别与累积生存率之间的关系。结果共纳入131例经介入治疗的B型AAD患者,其中男97例(74.0%),女34例(26.0%),中位随访时间2.1年。男性患者的吸烟史、胆固醇、白细胞计数、血红蛋白、肌酐和尿酸均高于女性患者,差异均有统计学意义(P<0.05),其他参数比较差异均无统计学意义(P>0.05)。男性患者院内死亡人数为10例(10.3%),女性患者院内死亡人数为3例(8.8%),两组比较差异无统计学意义(P=0.803)。Kaplan-Meier生存分析表明不同性别的患者在随访期间累积生存率差异无统计学意义(84.5%、82.4%;对数秩检验χ2=0.023,P=0.880)。结论性别和经介入治疗的B型AAD患者中的长期预后无明显相关性。
Objective To investigate the relationship between gender and long-term prognosis of patients with acute aortic dissection (AAD) undergoing interventional therapy. Methods A retrospective and observational study was conducted. All patients with type A AAD treated with interventional therapy between January 2012 and December 2012 were divided into two groups according to gender. The Kaplan-Meier survival curves were used to evaluate the differences in gender and cumulative survival rate The relationship between. Results A total of 131 patients with type A AAD were enrolled in this study, including 97 males (74.0%) and 34 females (26.0%) with a median follow-up of 2.1 years. Smoking history, cholesterol, white blood cell count, hemoglobin, creatinine and uric acid in male patients were significantly higher than those in female patients (P <0.05). There was no significant difference in other parameters (P> 0.05). In-hospital mortality was 10 (10.3%) for males and 3 (8.8%) for females, with no significant difference between the two groups (P = 0.803). Kaplan-Meier survival analysis showed that there was no significant difference in cumulative survival rate between follow-up patients (84.5%, 82.4%; log 2 test χ2 = 0.023, P = 0.880). Conclusion There is no significant correlation between gender and long-term prognosis in patients with type A AAD treated with intervention.