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目的:总结前列腺黏液腺癌(mucinous adenocarcinoma,MC)的临床病理特点、治疗方法及预后。方法:回顾性分析2002年1月~2014年10月收治的2例前列腺MC患者的临床病理资料:年龄分别为82和73岁,因排尿困难入院,tPSA分别为15.59ng/ml和210.1ng/ml,术前CT或MRI检查未见前列腺癌表现。1例行TURP术,术后行全雄激素阻断治疗;1例行前列腺穿刺活检确诊后行新辅助内分泌治疗3个月,然后行腹腔镜下前列腺癌根治术,术后部分切缘阳性,行辅助内分泌治疗及辅助放疗。结果:1例随访4年,排尿通畅,未见肿瘤转移。1例随访19个月,未见局部复发及转移。结论:前列腺MC临床罕见,病理学及免疫组织化学检查为确诊手段;内分泌治疗有效,根治性手术预后与普通前列腺癌类似。
Objective: To summarize the clinicopathological features, treatment and prognosis of mucinous adenocarcinoma (MC). Methods: The clinical and pathological data of two patients with prostate cancer who were admitted to our hospital from January 2002 to October 2014 were retrospectively analyzed. The patients were 82 and 73 years of age, admitted to hospital because of dysuria, tPSA was 15.59ng / ml and 210.1ng / ml, no preoperative CT or MRI examination of prostate cancer performance. 1 routine TURP surgery, after all androgen block treatment; 1 case of prostate biopsy confirmed by neoadjuvant endocrine therapy for 3 months, and then underwent laparoscopic radical prostatectomy, the positive margins after surgery, Auxiliary endocrine therapy and adjuvant radiotherapy. Results: One case was followed up for 4 years and voiding was unobstructed. There was no tumor metastasis. One case was followed up for 19 months, no local recurrence and metastasis were found. Conclusion: The clinical manifestations of prostate cancer are rare. The pathology and immunohistochemistry are the diagnostic methods. The endocrine therapy is effective. The prognosis of radical surgery is similar to that of ordinary prostate cancer.