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目的研究伊血安的长期毒性。方法观察连续给予大鼠受试药物所产生的毒性反应,根据严重程度、靶器官、恢复和发展情况,确定无毒反应剂量。结果以原生药干膏ig给予151.2、67.2、33.6g(生药)·kg-1伊血安4周(日剂量分别为临床拟用量的108、48、24倍),3个剂量组的凝血时间均缩短,大剂量组的血清肌酐含量稍增高,其余均未见明显的毒性反应;停药观察2周后,上述改变均恢复至正常水平,未见明显的迟缓毒性反应。结论伊血安长期用药对大鼠无明显毒性,按临床拟用剂量、用药途径和疗程是安全的。
Objective To study the long-term toxicity of ioxan. Methods To observe the toxic effects of continuous administration of test drugs in rats, and to determine the dose of non-toxic reaction according to the severity, target organs, recovery and development. Results The crude drug ig was given ig for 151.2,67.2,33.6g (crude drug) kg-1 Yi Xuean 4 weeks (daily doses were 108,48,24 times the clinical dosage), coagulation time Were shortened, high-dose group serum creatinine slightly increased, the rest were no significant toxicity; withdrawal observed 2 weeks after the above changes were returned to normal levels, no obvious delayed toxicity. Conclusion Yi-long-term use of drugs on rats no obvious toxicity, according to the clinical dose, route of administration and course of treatment is safe.