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背景:对类风湿关节炎(rheumatoidarthritis,RA患者关节肿痛的治疗一)直是风湿病研究领域的重点问题,临床上迫待需要一种疗效和安全性好的治疗药物。99Tc-亚甲基二膦酸盐一经用于风湿病治疗,其疗效和安全性即得到普遍关注。设计:以患者为研究对象的前后对照研究。目的:99Tc-亚甲基二膦酸盐改善RA患者关节功能障碍的特征。单位:一所大学医院风湿免疫科病房。对象:四川大学华西医院风湿科2000-03/2002-03收治的活动期RA住院患者67例,均符合美国风湿病协会1987年制订的RA诊断标准。年龄29～71岁,病程9～78月,其中男11例,女56例。全部病例均排除严重心、肝、肾等功能不全者,活动性胃肠病变者,血液及内分泌系统疾病者,过敏体质,以及孕期或哺乳期妇女。方法:67例RA患者经Tc-亚甲基二膦酸盐治疗,对其治疗前后关节99肿胀指数,关节压痛指数,握力,晨僵时间,休息痛和血沉,C反应蛋白等临床指标进行比较。疗程结束后进行综合评定,按症状和体征改善程度30%以上且ESR和CRP有所下降记为有效。同时观察记录副反应出现情况,对资料进行统计分析。结果:67例经Tc-亚甲基二膦酸盐治疗后,RA病情明显改善,治疗前99后关节肿胀指数,关节压痛指数,晨僵时间,休息痛和血沉,C反应蛋白等各项临床指标改善均有显著性意义(P<0.05)。该药物?
BACKGROUND: Rheumatoid arthritis (RA) is a key problem in the field of rheumatology. It is clinically necessary to have a curative and safe therapeutic drug. The efficacy and safety of 99Tc-methylene diphosphonate, once used in the treatment of rheumatism, has gained general attention. Design: A contextual study of patients. OBJECTIVE: 99Tc-methylene diphosphonate improves the characteristics of joint dysfunction in RA patients. Unit: a university hospital rheumatology ward. PARTICIPANTS: Sixty-six inpatients with active RA were admitted to Department of Rheumatology, West China Hospital of Sichuan University from March 2000 to March 2002, all of whom were in line with RA diagnostic criteria established by the American Rheumatism Association in 1987. Aged 29 to 71 years old, duration of 9 to 78 months, 11 males and 56 females. All cases were excluded severe heart, liver, kidney dysfunction, active gastrointestinal lesions, blood and endocrine system diseases, allergies, and during pregnancy or lactating women. Methods: Sixty-seven patients with RA were treated with Tc-methylene diphosphonate. The clinical indexes of joint 99 swelling index, joint tenderness index, grip strength, morning stiffness, resting pain, erythrocyte sedimentation rate and C-reactive protein were compared before and after treatment . After the end of the course of a comprehensive assessment, according to the symptoms and signs of improvement of more than 30% and ESR and CRP decreased marked effective. At the same time observe the occurrence of side effects recorded, the data for statistical analysis. Results: In 67 patients treated with Tc-methylene diphosphonate, the condition of RA was significantly improved. The clinical indexes such as joint swelling index, joint tenderness index, morning stiffness, resting pain, erythrocyte sedimentation rate and C-reactive protein The improvement of indexes was significant (P <0.05). The drug?