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摘要目的应用扩散张量成像探讨帕金森病(Parkinson’s disease,PD)病人合并或不合并痴呆时的认知状态与白质改变之间的关系。方法研究纳入20例PD病人、20例合并痴呆的帕金森病病人(PDD)以及年龄配对的20名健康对照者,均行MR扩散张量成像。用基于纤维束示踪的空间统计分析对比两组的平均扩散系数及各向异性分数图(FA图),生成胼胝体膝部的白质纤维束图,测量平均扩散系数以及FA值。结果 PDD组许多主要白质区的FA值显著低于健康对照组,PDD病人额叶前部白质以及胼胝体膝的FA值显
Abstract Objective To investigate the relationship between cognitive status and white matter changes in patients with Parkinson’s disease (PD) with or without dementia using diffusion tensor imaging. METHODS: Twenty patients with PD, 20 patients with Parkinson’s disease (PDD) with dementia, and 20 matched healthy controls were enrolled in this study. MR diffusion tensor imaging was performed. The average diffusion coefficient and anisotropy fraction (FA) of the two groups were compared by spatial statistical analysis based on tow tracing to generate the white matter fiber bundle map of the corpus callosum and the mean diffusion coefficient and FA value were measured. Results The FA values of many major white matter regions in PDD group were significantly lower than those in healthy control group. The FA values in frontal white matter and corpus callosum of PDD patients were significantly