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目的 观察维拉帕米和血液稀释疗法对兔心肌缺血再灌注损伤的保护作用。方法 结扎兔冠状动脉左室支中段，制成兔急性缺血再灌注模型，缺血１０ ｍｉｎ 时，ｉｖ 维拉帕米或用等容血液稀释法，观察在急性缺血和再灌注状态下心功能及血浆 Ｃ Ｐ Ｋ 及 Ｍ Ｄ Ａ 的变化。结果 维拉帕米（０２５ｍｇ·ｋｇ－ １） 和等容血液稀释都可以使模型兔心电图Ⅱ导联∑ Ｓ Ｔ 段压低， Ｌ Ｖ Ｓ Ｐ、＋ ｄ ｐ／ｄｔｍａｘ 、－ ｄｐ／ｄｔｍａｘ 增强，血浆 Ｃ Ｐ Ｋ和 Ｍ Ｄ Ａ 降低。结论 维拉帕米和等容血液稀释对心肌缺血再灌注损伤都有保护作用，但后者作用强于前者
Objective To observe the protective effect of verapamil and hemodilution on myocardial ischemia-reperfusion injury in rabbits. Methods The rabbit model of acute ischemia-reperfusion was established by ligating the middle part of the left ventricular branch of rabbit coronary arteries. At 10 minutes after ischemia, iv verapamil or isovolemic hemodilution was used to observe the changes of cardiac function during acute ischemia and reperfusion And plasma C P K and M D A changes. Results Both verapamil (025 mg · kg -1) and isovolemic hemodilution decreased the Σ S T segment of lead Ⅱ in ECG, and increased the values of V s P, d d / dt max and d d / dt max , Plasma C P K and M D A decreased. Conclusion Verapamil and isovolemic hemodilution have a protective effect on myocardial ischemia-reperfusion injury, but the latter effect is stronger than the former