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内毒素(LPS)是革蓝氏阴性杆菌(GNB)的主要致病物质,其毒力随量的增加而增大。内毒素在细菌菌体裂解时释放,可使机体的巨噬细胞释放肿瘤坏死因子(TNP)、白介素(IL)等炎症细胞因子,促使炎症、毒性休克、多脏器功能障碍综合征(MODS)的发生和发展。在我们已经拥有各种广谱、高效抗菌或杀菌药的今天,仍对GNB感染所致的败血症、脓毒症及MODS的防治没有取得根本性进展。对此,受到了学者们的日益关注与高度重视,对抗菌药诱发细菌LPS的释放问题作了大量研究,发现不同的抗菌药物诱导细菌LPS释放的潜能不同。本文着重综述不同抗菌药对细菌释放LPS及LPS水平与MODS的关系。
Endotoxin (LPS) is the main causative agent of gram-negative bacilli (GNB), and its virulence increases with increasing doses. Endotoxin is released during bacterial cell lysis and can release inflammatory cytokines, such as tumor necrosis factor (TNP) and interleukin (IL), to promote inflammation, toxic shock, multiple organ dysfunction syndrome (MODS) The occurrence and development of Today, we already have a variety of broad-spectrum, highly effective antibacterial or bactericidal drugs today, still no fundamental progress in the prevention and treatment of sepsis, sepsis and MODS caused by GNB infection. In this regard, scholars have been increasingly concerned about and attach great importance to antibacterial drug-induced release of bacterial LPS made a lot of research and found that different antibacterial drugs to induce bacterial LPS release of different potential. This article focuses on the different antimicrobial agents on bacterial release of LPS and LPS levels and MODS relationship.