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手性醇具有重要而广泛的应用价值,其不对称制备一直是有机合成领域的研究重点和热点.其中,不对称催化尤其是不对称催化氢化,以其高效、绿色和经济等优势正逐渐在手性醇的工业化制备中显示出巨大的潜能.首次对烯醇酯不对称催化氢化合成手性醇领域进行了综述,全面地介绍了各种结构类型和取代形式烯醇酯的不对称催化氢化研究现状,系统地分析了不同手性配体的过渡金属配合物催化剂的优势与不足,进而从新底物、新配体以及新金属等方面对该领域的发展方向进行了探讨.
Chiral alcohols have important and extensive application value, and their asymmetric preparation has been the focus and hotspot in the field of organic synthesis.Among them, asymmetric catalysis, especially asymmetric catalysis hydrogenation, is gradually being used in the fields of high efficiency, green and economy The industrialization of chiral alcohols has shown great potential.For the first time, the field of asymmetric catalytic hydrogenation of enol esters to the synthesis of chiral alcohols was reviewed and the asymmetric catalytic hydrogenations of various enantiomers and substituted enolates In this paper, the advantages and disadvantages of catalysts for transition metal complexes with different chiral ligands were systematically analyzed. Then the development of this field was discussed in terms of new substrates, new ligands and new metals.