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目的:研究DNA修复酶(O-methylguanine-DNA methyltransferase,MGMT)在乳腺癌中的表达及其临床意义。方法:乳腺癌和腺瘤标本共计143例,10%福尔马林固定,石蜡包埋,采用SABC免疫组织化学方法检测MGMT表达。结果:MGMT在乳腺癌和乳腺腺瘤中的阳性率分别为57.85%和13.64%,组间比较具有显著性差异。MGMT在乳腺癌中的表达与患者的年龄、淋巴结转移有关。结论:MGMT的异常表达与乳腺癌的淋巴结转移有关;MGMT可以作为判断乳癌发生和预后的重要指标;检测其表达可以指导临床上化疗方案的制定。
Objective: To study the expression of O-methylguanine-DNA methyltransferase (MGMT) in breast cancer and its clinical significance. Methods: A total of 143 breast cancer and adenoma specimens were fixed in 10% formalin and paraffin embedded. The expression of MGMT was detected by SABC immunohistochemistry. Results: The positive rates of MGMT in breast cancer and breast adenoma were 57.85% and 13.64%, respectively. There was significant difference between the two groups. MGMT expression in breast cancer patients with age, lymph node metastasis. Conclusion: The abnormal expression of MGMT is related to the lymph node metastasis of breast cancer. MGMT can be used as an important index to judge the occurrence and prognosis of breast cancer. Detecting the expression of MGMT can guide the formulation of clinical chemotherapy regimen.