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目的:比较他克林(tacrine,50μmol·kg~(-1),sc)拮抗莨菪类生物碱(0.05-50μmol·kg~(-1),ip)所致学习记忆障碍。方法:用两次性开阔和回避反应研究,小鼠于第一次实验前30min给药。结果:他克林对东莨菪碱(Sco)0.05-50μmol·kg~(-1)或阿托品(Atr)5-50μmol·kg~(-1)引起的学习和记忆障碍均有拮抗作用,以拮抗学习障碍最明显。他克林能改善樟柳碱(AT_3)和山莨菪碱(Ani)5-50μmol·kg~(-1)所致学习损伤,但不能拮抗其记忆损伤。Sco 0.5-50μmol·kg~(-1),AT_3和Atr5-50μmol·kg~(-1)完全拮抗,Ani 50μmol·kg~(-1)部分拮抗他克林引起的自主活动减少。结论:他克林优先改善莨菪类药物引起的被动回避反应学习障碍。
OBJECTIVE: To compare the effects of tacrine (50 μmol · kg -1, sc) on learning and memory dysfunction caused by antagonistic alkaloids (0.05-50 μmol · kg -1, ip). METHODS: With a double open and avoidance response study, mice were dosed 30 min prior to the first experiment. Results: Tacrine antagonized learning and memory deficits caused by 0.05-50 μmol · kg -1 of scopolamine (Sco) or 5-50 μmol · kg -1 of atropine (Atr) to antagonize learning disabilities The most obvious. Tacrine improved learning-induced injury induced by anisodine (AT_3) and Ani (5-50 μmol · kg -1), but did not antagonize memory impairment. Sco 0.5-50μmol · kg -1, AT 3 and Atr 5-50μmol · kg -1 completely antagonized the decrease of autonomic activity induced by Ani 50μmol · kg -1. Conclusion: Tacrine should give priority to improving passive avoidance learning disorders caused by antitussive drugs.