论文部分内容阅读
通过复制脊髓损伤(SCI)模型 ,用常氧、高压氧(HBO)、氮氧混合气、激素等分别处理各组大鼠后 ,取脊髓组织测兴奋性氨基酸(EAA ,包括天冬氨酸Asp及谷氨酸Glu)含量 ,以探讨HBO治疗SCI的机制。结果显示 ,损伤后 ,大鼠脊髓组织中EAA(Glu)含量明显升高 ,经不同处理后 ,除氮氧混合气组外 ,Glu含量均有所下降 ,以 0 2 5MPaHBO组和 0 2 5MPaHBO +激素组下降最明显 ,与损伤组比较有显著性差异 (P <0 0 1) ,与正常对照组比较则无显著性差异 ;0 2 5MPaHBO组与 0 1MPaHBO组比较及 0 2 5MPaHBO +激素组与激素组比较 ,均有显著性差异 (P <0 0 1)。提示HBO能通过减少组织中的EAA减轻SCI后的继发性损伤 ,恢复脊髓组织的功能 ,其中以0 2 5MPaHBO和 0 2 5MPaHBO并用激素治疗效果较佳
Spinal cord injury (SCI) model was used to treat the rats with normoxia, hyperbaric oxygen (HBO), nitrogen and oxygen mixed gas, hormones and so on. The excitatory amino acids (including aspartate Asp And glutamate Glu) content, to explore the mechanism of HBO treatment of SCI. The results showed that the contents of EAA (Glu) in rat spinal cord tissue were significantly increased after injury, and the content of Glu decreased after treated with 0,2 5 MPa HBO and 0,2 5 MPa HBO + There was no significant difference between the control group and the 0 2 5MPaHBO group and the 0 1MPaHBO group and the 0 2 5MPaHBO + group Hormone group, there was a significant difference (P <0.01). Hint HBO can reduce secondary injury after SCI by reducing EAA in tissues and restore the function of spinal cord tissue, of which 0,25MPaHBO and 0,25MPaHBO and hormone treatment better