Effect of chirality on conformation and cellular uptake of poly(S-(o-nitrobenzyl)-L,D-cysteine) poly

• 作 者: Yang Liu Chang-Ming Dong
• 机 构: Department of Polymer Science & Engineering,School of Chemistry and Chemical Engineering,Shanghai Ji
• 出 处: Chinese Chemical Letters
• 发表日期: 2017年04期
• 关键词: uptake cysteine conformation cytometry loaded distilled blends thoroughly chains

A series of poly(S-(o-nitrobenzyl)-L,D-cysteine) polypeptides with different chirality was synthesized and their molecular structures,secondary conformations,drug release and biological properties were thoroughly investigated.The chirality of the polypeptides had effect on secondary conformations and the cellular uptake behavior of the related nanoparticles.

A series of poly (S- (o-nitrobenzyl) -L, D-cysteine) polypeptides with different chirality was synthesized and their molecular structures, secondary conformations, drug release and biological properties were thoroughly investigated. The chirality of the polypeptides had effect on secondary conformations and the cellular uptake behavior of the related nanoparticles.