Effects of fused hirudin on activity of thrombin and function of platelets ~

• 作 者: 沈雳 陈少萍 蔡在龙 杨生生 秦永文
• 机 构: DepartmentofCardiology,DepartmentofBiochemistryandMolecularBiology
• 出 处: Journal of Medical Colleges of PLA
• 发表日期: 2005年2期
• 关键词: 水蛭素 凝血酶 酶活性 血小板 缩氨酸 止血方法 fused peptide antiplatelet antithrombin hirudin RGD

Objective: To investigate whether fused hirudin peptide has both antithrombin and antiplatelet functions. Methods: The core region of fused hirudin was the C-terminal tail of hirudin(hirudin53-64),which could bind to the anion binding exosite (ABE) of thr