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目的:分析2000—2019年中国胃癌发病率和死亡率变化趋势。方法:应用描述性流行病学方法。收集2000—2019年华盛顿大学健康测量及评价研究院全球疾病负担数据库（GBD）中中国胃癌发病率、死亡率、年龄标化发病率、年龄标化死亡率。观察指标：（1）2019年中国胃癌发病和死亡情况。（2）2019年中国胃癌年龄标化发病和死亡情况。（3）2000—2019年中国胃癌发病率变化趋势。（4）2000—2019年中国胃癌死亡率变化趋势。计数资料以绝对数、百分率和比值表示。以GBD估计的世界标准人口结构对胃癌发病率和死亡率进行标化，采用Joinpoint软件构建对数线性模型进行胃癌发病率和死亡率时间变化趋势分析。结果:（1）2019年中国胃癌发病和死亡情况：2019年中国胃癌发病人数612 821例，粗发病率为43.1/10万，年龄标化发病率为30.6/10万。发病人群中男性451 332例，女性161 489例，粗发病率分别为62.3/10万和23.2/10万，年龄标化发病率分别为47.4/10万和15.8/10万。2019年中国胃癌死亡人数421 539例，粗死亡率为29.6/10万，年龄标化死亡率为21.7/10万。死亡人群中男性298 514例，女性123 025例，粗死亡率分别为41.2/10万和17.6/10万，年龄标化死亡率分别为33.1/10万和12.2/10万。（2）2019年中国胃癌年龄标化发病和死亡情况：2019年中国胃癌发病人群中80岁81 113例，其中男性51 228例，发病占比为11.4%（51 228/451 332），女性29 885例，发病占比为18.5%（29 885/161 489）。2019年中国胃癌死亡人群中80岁80 161例，其中男性48 431例，死亡占为16.2%（48 431/298 514），女性31 730例，死亡占比为25.8%（31 730/123 025）。（3）2000—2019年中国胃癌发病率变化趋势：2000—2019年中国胃癌粗发病率由2000年的30.5/10万增加至2019年的43.1/10万，年平均变化率（AAPC）为1.9%［95%可信区间（n CI）为1.5~2.3，n P<0.05）。其中男性胃癌粗发病率由2000年的39.9/10万增加至2019年的62.3/10万，AAPC为2.4%（95%n CI为1.9~2.8，n P<0.05），女性胃癌粗发病率由2000年的20.5/10万增加至2019年的23.2/10万，AAPC为0.6%（95%n CI为0.4~0.9，n P<0.05）。2000—2019年中国胃癌年龄标化发病率由2000年的35.7/10万下降至2019年的30.6/10万，AAPC为-0.8%（95%n CI为-1.2~-0.3，n P<0.05）。男性胃癌年龄标化发病率由2000年的49.8/10万下降至2019年的47.4/10万，AAPC为-0.3%（95%n CI为 -0.6~0.0，n P<0.05），女性胃癌年龄标化发病率由2000年的22.8/10万下降至2019年的15.8/10万，AAPC为-1.9%（95%n CI为-2.2~-1.7，n P<0.05）。（4）2000—2019年中国胃癌死亡率变化趋势：2000—2019年中国胃癌粗死亡率由2000年的27.9/10万增加至2019年的29.6/10万，AAPC为0.3%（95%n CI为0.0~0.6，n P<0.05）。其中男性胃癌粗死亡率由2000年的35.9/10万增加至2019年的41.2/10万，AAPC为0.7%（95%n CI为0.3~1.1，n P<0.05），女性胃癌粗死亡率由2000年的19.4/10万下降至2019年的17.6/10万，AAPC为-0.5%（95%n CI为-0.8~-0.2，n P<0.05）。2000—2019年中国胃癌年龄标化死亡率由2000年的34.1/10万下降至2019年的21.7/10万，AAPC为-2.4%（95%n CI为-2.7~-2.1，n P<0.05）。其中男性胃癌年龄标化死亡率由2000年的47.5/10万下降至2019年的33.1/10万，AAPC为-1.9%（95%n CI为-2.2~-1.7，n P<0.05），女性胃癌年龄标化死亡率由2000年的22.4/10万下降至2019年的12.2/10万，AAPC为-3.2%（95%n CI为-3.4~-2.9，n P<0.05）。n 结论:2000—2019年我国胃癌发病率和死亡率呈下降趋势，60~69岁男性人群是胃癌的高危人群。“,”Objective:To analyze the incidence and mortality trends of gastric cancer from 2000 to 2019 in China.Methods:The descriptive epidemiologic method was conducted. Based on the Global Burden of Disease data from Institute for Health Metrics and Evaluation, the incidence rates, mortality rates, age-standardized incidence rates, age-standardized mortality rates of gastric cancer from 2000 to 2019 in China were collected. Observation indicators: (1) the incidence and mortality of gastric cancer in 2019 in China; (2) the age-standardized incidence and mortality of gastric cancer in 2019 in China; (3) the incidence trend of gastric cancer from 2000 to 2019 in China; (4) the mortality trend of gastric cancer from 2000 to 2019 in China. Count data were represented as absolute numbers, percentages with fractions. The incidence and mortality rates of gastric cancer were standardized by world standard population composition of Global Burden of Disease. Joinpoint software was used to construct a log-linear model for analysis of the changing trends of incidence and mortality rates over time in gastric cancer.Results:(1) The incidence and mortality of gastric cancer in 2019 in China: 612 821 gastric cancer cases occurred in China in 2019. The crude incidence rate was 43.1/100 000, and the age-standardized incidence rate was 30.6/100 000. There were 451 332 males, with the crude incidence rate of 62.3/100 000 and age-standardized incidence rate of 47.4/100 000. There were 161 489 females, with the crude incidence rate of 23.2/100 000 and age-standardized incidence rate of 15.8/100 000. The number of gastric cancer death was 421 539 in China in 2019, with the crude mortality rate of 29.6/100 000 and age-standardized mortality rate of 21.7/100 000. There were 298 514 males, with the crude mortality rate of 41.2/100 000 and age-standardized mortality rate of 33.1/100 000. There were 123 025 females, with the crude mortality rate of 17.6/100 000 and age-standardized mortality rate of 12.2/100 000, respectively. (2) The age-standardized incidence and mortality of gastric cancer in 2019 in China: the number of gastric cancer cases aged80 years was 81 113 in China in 2019, of which there were 51 228 males and 29 885 females, accounting for 11.4%(51 228/451 332) and 18.5%(29 885/161 489), respectively. The number of gastric cancer death cases aged80 years was 80 161 in China in 2019, of which there were 48 431 males and 31 730 females, accounting for 16.2%(48 431/298 514) and 25.8%(31 730/123 025), respectively. (3) The incidence trend of gastric cancer from 2000 to 2019 in China: the crude incidence rate of gastric cancer in China increased from 30.5/100 000 in 2000 to 43.1/100 000 in 2019, with an average annual percentage change (AAPC) of 1.9% (95%n confidence interval as 1.5 to 2.3, n P<0.05). The crude incidence rate of gastric cancer in males increased from 39.9/100 000 in 2000 to 62.3/100 000 in 2019, with an AAPC of 2.4% (95%n confidence interval as 1.9 to 2.8, n P<0.05). The crude incidence rate of gastric cancer in females increased from 20.5/100 000 in 2000 to 23.2/100 000 in 2019, with an AAPC of 0.6%(95%n confidence interval as 0.4 to 0.9, n P<0.05). The age-standardized incidence rate of gastric cancer in China decreased from 35.7/100 000 in 2000 to 30.6/100 000 in 2019, with an AAPC of -0.8% (95%n confidence interval as -1.2 to -0.3, n P<0.05). The age-standardized incidence rate of gastric cancer in males decreased from 49.8/100 000 in 2000 to 47.4/100 000 in 2019, with an AAPC of -0.3% (95%n confidence interval as -0.6 to 0.0, n P<0.05). The age-standardized incidence rate of gastric cancer in females decreased from 22.8/100 000 in 2000 to 15.8/100 000 in 2019, with an AAPC of -1.9% (95%n confidence interval as -2.2 to -1.7, n P<0.05). (4) The mortality trend of gastric cancer from 2000 to 2019 in China: the crude motality rate of gastric cancer in China increased from 27.9/100 000 in 2000 to 29.6/100 000 in 2019, with an AAPC of 0.3% (95%n confidence interval as 0.0 to 0.6, n P<0.05). The crude motality rate of gastric cancer in males increased from 35.9/100 000 in 2000 to 41.2/100 000 in 2019, with an AAPC of 0.7% (95%n confidence interval as 0.3 to 1.1, n P<0.05). The crude motality rate of gastric cancer in females decreased from 19.4/100 000 in 2000 to 17.6/100 000 in 2019, with an AAPC of -0.5% (95%n confidence interval as -0.8 to -0.2, n P<0.05). The age-standardized mortality rate of gastric cancer in China decreased from 34.1/100 000 in 2000 to 21.7/100 000 in 2019, with an AAPC of -2.4% (95%n confidence interval as -2.7 to -2.1, n P<0.05). The age-standardized mortality rate of gastric cancer in China in males decreased from 47.5/100 000 in 2000 to 33.1/100 000 in 2019, with an AAPC of -1.9% (95%n confidence interval as -2.2 to -1.7, n P<0.05). The standardized mortality rate of gastric cancer in females decreased from 22.4/100 000 in 2000 to 12.2/100 000 in 2019, with an AAPC of -3.2% (95%n confidence interval as -3.4 to -2.9, n P<0.05).n Conclusions:The incidence and mortality rates of gastric cancer in China from 2000 to 2019 present a downward trend. Male patients aged 60-69 years are at high risk of gastric cancer.