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血管内皮生长因子(VEGF)是最具特征性的血管新生调节因子,与其特异性受体(VEGFR)结合后可促进内皮细胞增殖和分化,增加微血管通透性,诱导血管新生,触发肿瘤细胞的生长并抑制其凋亡。VEGF表达及其信号通路的失调在血液系统恶性肿瘤的发病机制和临床表现方面发挥至关重要的作用,因此直接或间接作用于VEGF及其受体的治疗手段为抑制恶性肿瘤骨髓血管新生、逆转多药耐药提供了全新的方法,从而进一步提高治疗效果。近年来,RNA干扰技术作为一项全新的VEGF抑制体系倍受关注,其中靶向VEGF/VEGFR的小分子干扰RNA可以抑制VEGF表达,从根本上诱导相应基因的沉默。
Vascular endothelial growth factor (VEGF) is the most characteristic regulatory factor of angiogenesis, combined with its specific receptor (VEGFR) can promote endothelial cell proliferation and differentiation, increase microvascular permeability, induce angiogenesis, trigger tumor cells Grow and inhibit its apoptosis. The dysregulation of VEGF expression and its signaling pathways play a crucial role in the pathogenesis and clinical manifestations of hematological malignancies. Therefore, the direct and indirect therapeutic approaches to VEGF and its receptors are to inhibit the angiogenesis of malignant tumors and reverse Multidrug resistance provides a completely new approach to further improve the therapeutic effect. In recent years, RNA interference technology has drawn much attention as a new VEGF inhibition system. The small interfering RNA targeting VEGF / VEGFR can inhibit the expression of VEGF and fundamentally induce the silencing of the corresponding gene.