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目的研究胃液中维生素Ｃ（ＶｉｔＣ）浓度与幽门螺杆菌（Ｈｐ）感染和胃、十二指肠疾病的关系。方法抽取病人空腹胃液和血液，用高铁还原法测定血浆和胃液中的ＶｉｔＣ浓度；Ｈｐ通过尿素酶试验和病理ＷＳ染色确定。结果Ｈｐ阳性病人胃液中ＶｉｔＣ浓度明显低于Ｈｐ阴性病人；胃液中ＶｉｔＣ浓度与慢性胃炎的炎症程度无关，但在活动性胃炎病人胃液中ＶｉｔＣ浓度明显低于非活动性胃炎病人；与非溃疡性消化不良病人相比，活动期胃溃疡和十二指肠溃疡病人的ＶｉｔＣ浓度明显降低。结论Ｈｐ感染可导致胃液中ＶｉｔＣ浓度降低，这可能是Ｈｐ与胃癌和消化性溃疡的发生相关联的重要因素
Objective To study the relationship between vitamin C (VITC) in gastric juice and Helicobacter pylori (Hp) infection and gastric and duodenal diseases. Methods The fasting gastric juice and blood were drawn from the patients. The concentrations of VitC in plasma and gastric juice were determined by high-speed iron reduction. Hp was determined by urease test and pathological WS staining. Results The concentration of VitC in gastric juice of Hp positive patients was significantly lower than that of Hp negative patients. The concentration of VitC in gastric juice was not related to the degree of inflammation of chronic gastritis, but the concentration of VitC in gastric juice of patients with active gastritis was significantly lower than that of patients with inactive gastritis. Compared with patients with dyspepsia, active gastric ulcer and duodenal ulcer patients significantly decreased the concentration of VitC. Conclusions Hp infection can lead to the decrease of VitC concentration in gastric juice, which may be an important factor in the association of Hp with gastric cancer and peptic ulcer