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目的 探讨视觉诱发电位的快速提取及其临床应用的可行性。方法 采用Galileo视觉诱发电位检测系统进行VEP常规检查和快速提取 ,即每例均用前 5次行少次平均 ,经小波变换、独立分量分析联合的最优滤波信号处理。检测 36例视神经病患者 ,并以 4 6例正常健康人为对照组 ,对以上两种检查方法所得的VEP参量进行测量。最后以传统检测方法的P10 0潜伏期为金标准 ,验证新方法的敏感性、特异性、准确性。结果 新方法的敏感性为 95 .6 % (4 3/45 ) ,特异性为 95 .0 % (113/119) ,准确性为 95 .1% (15 6 /16 4 )。Kappa为 0 .88。 结论 ①新方法与传统方法相比 ,对视觉系统病变的检测结果相似 ;②新方法对某些视觉系统亚临床病变较为敏感 ;③新方法可明显减少刺激次数 ,经进一步完善 ,将很有可能临床实时应用
Objective To explore the rapid extraction of visual evoked potential and its feasibility of clinical application. Methods Galileo visual evoked potentials detection system was used for VEP routine examination and rapid extraction. That is to say, each case was treated with the least average of the first 5 rows and the best filtered signal combined by wavelet transform and independent component analysis. 36 cases of optic neuropathy patients were detected, and 36 normal healthy subjects as control group, the VEP parameters obtained by the above two methods were measured. Finally, the traditional detection method P10 0 latency as the gold standard to verify the sensitivity, specificity and accuracy of the new method. Results The sensitivity and specificity of the new method were 95.6% (4 3/45), 95.0% (113/119) and 95.1% (156/164) respectively. Kappa is 0.88. Conclusion ① The new method is similar to the traditional method in detecting the visual system lesions; ② The new method is sensitive to the subclinical lesions of some visual systems; ③ The new method can significantly reduce the number of stimuli, and it is likely to be further improved Clinical real-time applications