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镉是一种重要的职业和环境污染物,通过呼吸道或消化道进入动物和人体内。人类摄取镉的主要形式是吸烟和饮食2条途径。金属硫蛋白(MT)主要存在于小肠、肝脏和肾脏中,其生物学作用之一就是对重金属的解毒。正常小鼠的肠MT含量很低,锌(Zn)和镉均可诱导肠粘膜合成MT。因此本文采用Zn预先诱导小肠产生MT以研究MT对镉吸收和组织分布的影响。动物选用大鼠,随机分成2组,一组为氯化镉染毒组,另一组为对照(氯化镉染毒同时给予锌处理)。研究发现预先经100 mg
Cadmium is an important occupational and environmental pollutant that enters animals and humans through the respiratory or gastrointestinal tract. The main form of human intake of cadmium is smoking and eating two ways. Metallothionein (MT) is found mainly in the small intestine, liver and kidney, and one of its biological roles is to detoxify heavy metals. The intestinal mucosa content of normal mice is very low, and zinc (Zn) and cadmium can induce intestinal mucosal synthesis of MT. In this paper, Zn was used to induce MT in the small intestine to study the effect of MT on cadmium absorption and tissue distribution. Rats were randomly divided into 2 groups: one group was cadmium chloride exposure group and the other was control (cadmium chloride exposure plus zinc treatment). The study found that by 100 mg