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目的对腔隙性脑梗死后抑郁(PSD)患者进行多种相关因素的研究,为PSD患者早期诊断和干预治疗提供依据。方法采用病例-对照研究方法,选用符合标准的2010年1月至2011年4月住院的所有初发腔隙性脑梗死患者,其中抑郁患者为病例组,其余患者为对照组,对研究资料先进行单因素分析,然后进行多因素非条件Logistic多元回归分析。结果 138例患者中能够完成所有调查任务的123例,其中抑郁病患者43例。经分析筛选神经功能缺损评分、病灶数量、基底节区病变3个因素为PSD的危险因素,受教育程度为PSD的保护因素。结论神经功能缺损程度为PSD最重要的危险因素,受较高水平教育为PSD的保护因素。
Objective To study a variety of related factors in patients with post-lacunar depression (PSD) and provide evidence for the early diagnosis and intervention of PSD patients. Methods A case-control study was conducted. All patients with newly diagnosed lacunar infarction who were hospitalized from January 2010 to April 2011 were selected. Among them, the patients with depression were the case group and the other patients were the control group. Univariate analysis, and then multivariate non-conditional Logistic multiple regression analysis. Results Among the 138 patients, 123 were able to complete all the investigation tasks, including 43 patients with depression. After analysis and screening of neurological deficit score, the number of lesions, basal ganglia lesions three factors for PSD risk factors, educational level as PSD protection factor. Conclusion The degree of neurological deficit is the most important risk factor of PSD, which is protected by higher education level.