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观察电刺激大鼠坐骨神经引起海马齿状回诱发场电位的变化,探讨外周传入信息在海马的可塑性以及海马在痛觉调制中的作用。共记录了28只大鼠海马齿状回诱发场电位,平均幅度(23.73±1.12)μV,潜伏期(198.46±5.91)ms。不同条件刺激引起的反应包括:高频条件刺激使海马齿状回诱发场电位幅度降低;低频条件刺激使海马齿状回诱发场电位幅度增大。结果提示,电刺激坐骨神经可在海马齿状回记录到诱发场电位,不同的条件刺激可引起诱发场电位的不同变化,表现为突触传递效能增强或降低,海马对外周传入信息及痛觉起一定的调制作用。
To observe the changes of electrical potential in hippocampal dentate gyrus induced by electrical stimulation of sciatic nerve in rats and to explore the plasticity of peripheral afferent information in the hippocampus and the role of hippocampus in pain modulation. A total of 28 rat hippocampal dentate gyrus induced field potential, the average amplitude (23.73 ± 1.12) μV, the incubation period (198.46 ± 5.91) ms. Response to different conditions of stimulation include: high-frequency stimuli to dentate gyrus dentate gyrus field potential amplitude decreased; low-frequency stimulus to the hippocampal dentate gyrus induced field amplitude. The results suggest that the electrical stimulation of the sciatic nerve can record the induced field potential in the dentate gyrus of the hippocampus. Different conditions can induce different changes in the induced field potentials, showing the enhancement or decrease of the synaptic transmission potency. The hippocampal afferent information and pain sense Certain modulation effect.