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本文在海拔10m(青岛)、2260m(青海西宁)和3700m(青海玉树)三个高度,用放射免疫法,测定445例健康人血四碘甲腺原氨酸(T_4)、三碘甲腺原氨酸(T_3)、3,3’,5’三碘甲腺原氨酸(rT3)皮质醇(F)和醛固酮(ALD)含量。结果发现:(1)高海拔地区世居藏族与有15年以上移居史的汉族居民五项测值间无显著差别(P>0.05);(2)高海拔地区居民T_3、T_4、F和ALD含量降低(P<0.05～0.001),而rT3则升高(P<0.01)。这些变化的生理意义,可能反映了高原居民对低氧环境的一种慢性适应机制。在某些高原疾病防治中,适当应用肾上腺皮质激素,可能有一定临床价值。
In this study, 445 healthy subjects were tested for blood levels of tetraiodothyronine (T_4), triiodothyronine (GTPA) by radioimmunoassay at three altitudes of 10m (Qingdao), 2260m (Xining) and 3700m (T_3), 3,3 ’, 5’ triiodothyronine (rT3), cortisol (F) and aldosterone (ALD). The results showed that: (1) There was no significant difference between the five ethnic populations inhabiting the Tibetan ethnic group in the high altitude area and those with a history of more than 15 years (P> 0.05); (2) The residents T_3, T_4, F and ALD (P <0.05 ~ 0.001), while rT3 increased (P <0.01). The physiological significance of these changes may reflect a chronic adaptive mechanism of plateau residents to hypoxia. In some prevention and treatment of altitude sickness, proper use of adrenal cortex hormones, may have some clinical value.