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目的探讨阿托伐他汀对H型高血压患者血压及血浆Hcy、hs-CRP、颈动脉内膜中膜厚度的影响。方法将2013年9月~2016年5月于我院确诊为H型高血压的82例患者纳入研究并回顾分析,对照组40例采用常规降压治疗,观察组42例联合阿托伐他汀治疗,6个月为一疗程,比较两组临床疗效差异。结果治疗后,患者收缩压及舒张压均较前降低,但观察组改善更显著,P<0.05;治疗后患者Hcy、hsCRP、颈动脉内膜中膜厚度均降低,但观察组幅度更低,差异显著,P<0.05。结论阿托伐他汀治疗H型高血压疗效显著,可更好地改善血压,降低血浆Hcy、hs-CRP等指标,并可更小程度减少颈动脉内膜中膜厚度,值得推广。
Objective To investigate the effects of atorvastatin on blood pressure and plasma Hcy, hs-CRP and carotid intima-media thickness in patients with Hypertension. Methods Eighty-two patients diagnosed as Hypertension in our hospital from September 2013 to May 2016 were retrospectively analyzed. Forty patients in the control group were treated with conventional antihypertensive therapy and 42 in the observation group combined with atorvastatin , 6 months for a course of treatment, the difference between the two groups clinical efficacy. Results After treatment, systolic and diastolic blood pressure decreased, but the improvement in the observation group was more significant (P <0.05). After treatment, the Hcy, hsCRP and carotid intima-media thickness decreased, but the observation group had a lower amplitude, The difference was significant, P <0.05. Conclusions Atorvastatin is effective in treating Hypertension, which can improve blood pressure, reduce plasma Hcy, hs-CRP and other indicators, and can reduce carotid artery intima-media thickness to a lesser extent.