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Objective: To evaluate the efficacy of oxymatrine in treating chronic hepatitis C and its mechanism. Methods: Forty-three patients were divided randomly into two groups. Thetreated group was given oxymatrine, and the control group the general liver protective agents for 3 months. Results: HCVRNA of 8 in 17 cases (47. 1 % ) of the treated group converted to negative, while in 18 cases of the control group, the negative conversion only found in 1 patient (5. 6 % ), the difference was significant (P < 0. 05 ). The normalization rates of serum alanine transaminase (ALT) of the treated group after treatment was higher than those of the control group, but after 3 months treatment, the normalization rates of the two groups were not different significantly. Plasma level of soluble interleukin-2 receptor and serum level of collagen type Ⅳ in the treated group were lowered significantly after treatment, but in the control group there was no significant change, the difference between the two groups was significant (P < 0. 01, P< 0. 05). Conclusion: Oxymatrine is effective in inhibiting proliferation of HCV, antagonising liver fibrosis and regulating immune reaction of the host, so it could be a safe, effective drug in treating chronic hepatitis C.Original article on CJIM(Chin) 1998; 18(4): 227
Objective: To evaluate the efficacy of oxymatrine in treating chronic hepatitis C and its mechanism. Methods: Forty-three patients were divided randomly into two groups. Thetreated group was given oxymatrine, and the control group the general liver protective agents for 3 months. Results (47.1%) of the treated group converted to negative, while in 18 cases of the control group, the negative conversion only found in 1 patient (5.6%), the difference was significant ( P <0.05). The normalization rates of serum alanine transaminase (ALT) of the treated group after treatment was higher than those of the control group, but after 3 months treatment, the normalization rates of the two groups were not more significantly. Plasma level of soluble interleukin-2 receptor and serum level of collagen type Ⅳ in the treated group were lowered significantly after treatment, but in the control group there was no significant change, the difference between the two g roups was significant (P <0.01, P <0.05). Conclusion: Oxymatrine is effective in inhibiting proliferation of HCV, antagonising liver fibrosis and regulating immune reaction of the host, so it could be a safe, effective drug on treating chronic hepatitis C. Original article on CJIM (Chin) 1998; 18 (4): 227