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目的观察氟比洛芬酯-丙泊酚混合液在无痛人工流产中的临床效果。方法选择妊娠4~12周拟行人工流产术妇女160例,随机分为A、B组,每组80例。A组选择氟比洛芬酯-丙泊酚麻醉,B组用芬太尼复合丙泊酚麻醉。两组均至眼睑反射消失后开始手术,术中如有体动,追加首次剂量的1/3。记录发生丙泊酚注射痛例数;记录给药前(T0)、手术开始时(T1)、扩宫即刻(T2)、吸宫即刻(T3)、术毕即刻(T4)、清醒即刻(T5)、清醒后15min(T6)时点HR、MAP和SpO2;记录手术时间、苏醒时间、丙泊酚用量、镇痛效果、呼吸抑制、术后恶心、呕吐情况及术后10、30min VAS疼痛评分。结果两组妇女手术时间、苏醒时间、丙泊酚用量、镇痛效果及术后10min VAS疼痛评分差异无统计学意义(P>0.05)。两组妇女术中HR、MAP平稳,A组T1~T3时点SpO2高于B组(P<0.05)。A组术中呼吸抑制发生率低于B组(13.8%vs.42.5%)(P<0.05);与B组比较,A组丙泊酚注射痛以及恶心、呕吐发生率降低,术后30min VAS疼痛评分减少(P<0.05)。结论氟比洛芬酯-丙泊酚混合液与芬太尼复合丙泊酚麻醉效果相当,不良反应少,安全性高,更适合于无痛人工流产术。
Objective To observe the clinical effect of flurbiprofen ester and propofol mixture in painless artificial abortion. Methods 160 cases of women who underwent induced abortion 4 to 12 weeks gestation were randomly divided into A and B groups, 80 cases in each group. Group A was treated with flurbiprofen-ester-propofol and group B was anesthetized with fentanyl and propofol. Two groups were to eyelid disappear after the surgery began, if any body movement, additional first dose of 1/3. The number of cases of propofol injection was recorded. The time before injection (T0), at the beginning of operation (T1), immediately after dilatation (T2), immediately after dilation (T3), immediately after operation (T4) ), And HR, MAP and SpO2 at 15min (T6) after awake. The time of operation, recovery time, dosage of propofol, analgesic effect, respiratory depression, postoperative nausea and vomiting, VAS pain score . Results The operation time, recovery time, dosage of propofol, analgesic effect and VAS pain scores at 10 min after operation in the two groups showed no significant difference (P> 0.05). The HR and MAP of the two groups of women were stable, and the SpO2 of group A was higher than that of group B at T1 ~ T3 (P <0.05). In group A, the incidence of intraoperative respiratory depression was lower than that in group B (13.8% vs.42.5%, P <0.05). Compared with group B, the incidence of nausea and vomiting was decreased in group A, Pain scores decreased (P <0.05). Conclusion The combination of flurbiprofen-propofol and fentanyl with propofol has similar anesthetic effects, less adverse reactions, high safety and is more suitable for painless abortion.