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柳氮磺胺吡啶是一有效的,具有缓慢作用的抗类风湿性关节炎药物。可目前仍无确定其是否对关节损伤也产生有益作用。作者用柳氮磺胺吡啶和羟氯喹双盲法治疗类风湿性关节炎患者,经48周的观察后,对其手和足X线照片进行评价。 60例典型类风湿关节炎患者参加了试验。病人随机接受柳氮磺胺吡啶或羟氯喹,前者初剂量每日500mg,此后每4日增加500mg,直到每日维持量2000mg;后者初剂量200mg,每日2次,持续24周后改为每日1次,剂量不变。在整个试验中,每4周进行一次临床和实验室观测。在24周和48周进行手、腕和足的直接X线摄片。
Sulfasalazine is a potent, slow-acting anti-rheumatoid arthritis drug. It is still not clear whether this has a beneficial effect on joint damage. The authors used sulfasalazine and hydroxychloroquine double-blind treatment of rheumatoid arthritis patients, after 48 weeks of observation, the hand and foot X-ray photographs were evaluated. Sixty patients with typical rheumatoid arthritis participated in the trial. Patients randomized to receive sulfasalazine or hydroxychloroquine, the former initial dose of 500mg daily, then every 4 days increased 500mg until the daily maintenance dose of 2000mg; the latter dose of 200mg, 2 times a day for 24 weeks later changed to Day 1, the same dose. Clinical and laboratory observations were performed every 4 weeks throughout the trial. Direct radiography of hands, wrists and feet at 24 weeks and 48 weeks.