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氨苯砜(DDS)是治疗环状肉芽肿(GA)的一种有效药物。作者报告1例 GA 患者,于用 DDS治疗7周后诱发粒细胞缺乏症,并伴发败血症。患者女,50岁,于肘、膝发生典型 GA3年,无内科病或用药史。疗前作全血检查正常。DDS 的最初用量为50mg,每日2次。5周后,未见疗效,改为50mg,每日3次。2周后,血细胞计数示中性粒细胞减少,乃停止 DDS 治疗。8天后因发热、嗜睡和肛周疼痛而住院。体检发现,体温39.5℃,
Dapsone (DDS) is a potent drug for the treatment of granuloma annulare (GA). The authors report 1 patient with GA who developed agranulocytosis 7 weeks after treatment with DDS and was associated with sepsis. Female, 50 years old, at elbow, knee typical GA3 years, no medical history or medication. Whole blood examination before treatment for normal. The initial dose of DDS 50mg, 2 times a day. After 5 weeks, no effect, changed to 50mg, 3 times a day. Two weeks later, hematocrit showed neutropenia, which stopped DDS treatment. 8 days later due to fever, drowsiness and perianal pain and hospitalization. Physical examination found that body temperature 39.5 ℃,