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茶碱可用于防治支气管哮喘,其缺点为作用和安全范围狭窄,且消除迅速,故儿童需多次给药。因此,已生产出多种控释制剂试图克服上述缺点。然而,有时饮食可妨碍控释制剂中茶碱的吸收速度和程度。本文评估食物对Theolong颗粒剂及Theodur-G两种控释制剂中茶碱的释放速率及释放度、生物利用度的影响。 5例22～33岁健康志愿者禁食一夜,标准或富含脂肪早餐30分钟后口服含200mg茶碱的Theolong颗粒剂或Theodur-G,按随机交叉设计,2次用药间隔1周。受试者在
Theophylline can be used for the prevention and treatment of bronchial asthma, its shortcomings for the role and scope of safety is narrow, and eliminate quickly, so children need multiple administrations. Therefore, a variety of controlled release formulations have been produced that attempt to overcome the above drawbacks. However, sometimes the diet can interfere with the rate and extent of theophylline absorption in the controlled release formulation. This article evaluates the effect of food on the release rate, release and bioavailability of theophylline from Theolong granules and Theodur-G. Five healthy volunteers aged 22-33 were fasted for one night. Theolong granules or Theodur-G with 200 mg theophylline were orally administered 30 minutes after standard or fat-rich breakfast. Subjects at