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1964年 Vaumonder 等报导使用容量扩张液体使细胞外液急性增多时,高血压患者排钠利尿的速率较正常人为快。Krakoff 等注意到在低肾素型者尤为明显。嗣后许多作
In 1964, Vaumonder et al reported that the use of volume expansion of liquid to make extracellular fluid increased acutely, the rate of sodium in patients with hypertension and diuretic faster than normal. Krakoff et al. Noted that this is especially true in patients with low renin. Many later