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目的:通过犬动物实验,检测喷砂处理螺纹柱状纳米氟磷灰石聚醚醚酮材料(nFA/PEEK)的生物相容性和成骨性能。方法:将喷砂和非喷砂nFA/PEEK各10颗,延期植入6只犬下颌前磨牙区,术后8周和12周末各随机处死3只,种植体骨标本行同步辐射扫描后,制作非脱钙种植骨组织切片,四环素荧光标记测定动态参数骨结合率(BIC)和矿化沉积率(MAR)。苦味酸品红染色测定骨的静态参数。采用SPSS18.0软件包对数据进行统计学分析。结果:同步辐射扫描8周,种植体骨床界面呈现连续接触,新生骨组织长入螺纹凹陷处;12周均基本形成骨结合,喷砂组新骨形成和成熟更快。8周末的BIC(63.34%)和MAR(1.51μm/d)均显著高于(P<0.05)未喷砂组种植体(22.97%,1.34μm/d);12周末喷砂组的BIC(75.49%)显著高于(P>0.05)未喷砂组(55.35%),但MAR(1.28μm/d对1.27μm/d)无显著差异。骨静态学参数喷砂组骨体积分数和骨小梁数量显著高于非喷砂组,但骨小梁间隔显著低于非喷砂组(P<0.05),表明喷砂组更有利于骨量的增加,但骨小梁厚度无显著差异。结论:本研究表明,喷砂处理nFA/PEEK种植体具有良好的生物相容性,与其骨床结合紧密。
OBJECTIVE: To detect the biocompatibility and osteogenesis properties of nAF / PEEK threaded columnar nanofluidite by the animal experiment. Methods: Ten pieces of nFA / PEEK were sandblasted and non-grit blasted. Six mandibular premolar teeth were implanted delaminated. Three rabbits were randomly sacrificed at 8 weeks and 12 weeks after operation. Non-decalcified bone tissue sections were prepared and tetracycline fluorescent labeling was used to determine the dynamic parameters of bone incorporation rate (BIC) and mineralization deposition rate (MAR). Determination of the static parameters of bone by picric acid magenta staining. SPSS18.0 software package for statistical analysis of the data. Results: At the 8th week of synchrotron radiation scanning, the bone-bed interface of the implants showed continuous contact, and the new bone grew into the thread depression. Bone bond was basically formed at 12 weeks and the new bone formed and matured faster in the blast-blasted group. The BIC (63.34%) and MAR (1.51μm / d) in the 8th weekend were significantly higher than those in the non-blast group (22.97%, 1.34μm / d) %) Was significantly higher than that of non-grit blasted group (55.35%), but there was no significant difference between MAR (1.28μm / d and 1.27μm / d). Bone static parameters Sand blasting group, bone volume fraction and trabecular number was significantly higher than non-blast group, but trabecular spacing was significantly lower than the non-blast group (P <0.05), indicating that the blast group is more conducive to bone mass There was no significant difference in trabecular thickness. CONCLUSIONS: This study shows that nFA / PEEK implants have good biocompatibility and are tightly bound to the bone bed.