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采用骨组织病理学方法对去势雌山羊骨组织结构变化进行动态观察。１．５岁左右雌性成都山羊１０只，平均体重２２ｋｇ左右，随机分为对照组５只，双侧卵巢切除组５只。术前，术后６０天，１２０天和１８０天分别取髂前上嵴骨活检组织作病理组织形态学观察。结果显示：在整个研究过程中对照组的骨组织结构维持相对恒定，而双侧卵巢切除组在术后６０天则出现轻度骨小梁数量减少，相互连接分离；术后１２０天到１８０天骨小梁数量进一步减少，骨小梁变细小，宽度降低，出现钮扣样变，骨髓腔扩大，呈典型的骨量减少的病理学改变。本实验结果为骨质疏松模型的进一步研究提供了实验资料
Bone histopathology was used to observe the changes of the bony structure of castrated female goats. About 1.5 years old female Chengdu goat 10, the average weight of about 22kg, were randomly divided into control group 5, bilateral ovariectomy group 5. Preoperative, postoperative 60 days, 120 days and 180 days were taken anterior superior iliac crest bone biopsy for histopathological observation. The results showed that in the whole study, the structure of the bone in the control group remained relatively constant, while the bilateral ovariectomy group showed a slight decrease in the number of trabecular bone at 60 days after operation, and connected with each other; after 120 days to 180 days The number of trabecular further decreased, the trabecular bone became smaller, the width decreased, the appearance of button-like changes and the enlargement of the bone marrow cavity showed the pathological changes of typical osteopenia. The experimental results provide experimental data for the further study of osteoporosis model